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Medications That Cause Dry Mouth

Sherry Haynes is currently pursuing a PharmD degree and has experience in both the clinical and management sides of pharmacy.

medications-that-cause-dry-mouth

Dry mouth is a common problem in many people, especially the elderly and women. Dry mouth which is otherwise medically termed as "xerostomia" usually results from salivary gland hypofunction which can lead to low salivary flow rates. Nevertheless, having a dry mouth does not necessarily indicate that the salivary glands are not functionally normally. Many patients tend to have a dry mouth sensation even with normal salivary flow rates.

People with dry mouth may experience a burning sensation, altered taste, bad-smelling mouth, difficulty in speaking, chewing, swallowing, and wearing dentures. The patient often feels the need to drink liquids to help in swallowing food. In worse cases, dry mouth may result in oral mucosal soreness, angular cheilitis and oral candidiasis.

Causes of Dry Mouth

Many causes have been associated with dry mouth. The most common of them are medications, psychological conditions such as stress and anxiety, salivary gland disorders such as Sjogren's syndrome, systemic diseases particularly hypertension, diabetes, rheumatic diseases, asthma and radiotherapy of head and neck. Tobacco, smoking, coffee and soft drinks containing caffeine can also cause dryness in the mouth.

Dry mouth is more common among women and the prevalence seems to increase after 50 years of age. Age may be a risk factor because there is an increase in drug intake for chronic disorders among elderly people. More medications mean there is more probability that medication with dry mouth as a side effect is being consumed.

How is Medication Induced Dry Mouth Diagnosed?

You will be made to answer a series of questions and/or a visual analogue scale may be used where you will be asked to rate the severity of the dryness in your mouth.
Osailan et al. proposed several helpful signs of having a dry mouth some of which are

  • frothy saliva
  • no saliva pooling in the floor of the mouth
  • fissured tongue
  • cervical caries in more than two teeth

List of Medications that Cause Dry Mouth and How they Work

More than 400 drugs are associated with dry mouth as a side effect. Most of these drugs are used for common systemic diseases.

Although several mechanisms have been explained in the dry mouth due to drugs. It is important to understand that the mechanism of causing this condition depends entirely on the type of the drug and how it works.

Saliva consists of two components each secreted by an independent mechanism. The first component is fluid which includes ions and is produced by parasympathetic stimulation. The second is a protein component released mainly in response to sympathetic stimulation. The parasympathetic and sympathetic stimulation is under the control of the autonomic nervous system. Apart from this, hormones may also modulate the composition of the salivary gland.

1. Action on the Cholinergic System

Explaining simply, our body has an autonomic nervous system which acts unconsciously and regulates several of our bodily functions such as digestion, heart rate and salivary flow rate. These organs (namely heart, smooth muscles and exocrine glands) contain receptors which help mediate the action.

The receptors can be inhibited or stimulated by the action of the peripheral nervous system. Our salivary gland is also served with one of these receptors, namely the cholinergic receptor. A chemical released by nerve cells called neurotransmitter acetylcholine sends a signal to cells of salivary glands stimulating the flow of saliva.

Similarly, the same cholinergic receptor is present on the urinary bladder. In patients with urinary incontinence, an anticholinergic medication is given to inhibit the cholinergic receptor to reduce incontinence. This medication could target cholinergic receptors on the urinary bladder as well as salivary gland inhibiting the flow of saliva also.

The drugs that work by this mechanism are given in the below table

Medications that work by Acting on Cholinergic System

1. Antidepressants

Duloxetine, Doxepin, Escitalopram

2. Medications used for Urinary Incontinence

Oxybutynin, tolterodine, fosterodine, trospium chloride, terazosin, propiverine hydrochloride, tamsulosin (acts by mechanism 2)

3. Antipsychotics

Fluphenazine enanthate or decanoate, Olanzapine, Quetiapine, Risperidone, Tiapride, Pipamperone, Donepezil

4. Diuretic agents and Psychotropics

Furosemide, Torsemide., Spironolactone, Triamterene, Bumetanide, Metalozone, Hydrochlorothiazide

2. Action on Sympathetic System

In addition to cholinergic innervation, the salivary glands also receive sympathetic innervation (alpha 1 and beta-receptors) Activation of either system will cause an increased secretion from salivary glands. For example, antihypertensive drugs such as clonidine and guanfacine inhibit alpha 2-adrenoceptor to cause a fall in blood pressure but also decreasing salivary flow.

The medicines that work by such mechanism are included in the table below.

Medicines that Cause Dry Mouth by Acting on Sympathetic System

5. Blood Pressure Lowering Medicines

Clonidine. Guanfacine, Alphamethyl DOPA

NIfedipine, Verapamil, Diltiazem ( work by another mechanism )

6. Antidepressants

Fluoxetine, Venelafaxine, Nefazodone, Reboxetine, Bupropion hydrochloride

7. Appetite Suppressants

Sibutramine, Fenfluramine, Phentermine, Herbal supplement (Ma huang and kola nut)

8. Cold Suppressants

Pseudoephedrine, Cetrizine, Loratadine plus pseudoephedrine sulphate

9. Muscle Relaxer

Tizanidine

10. Migraine Relief medicine

Rizatriptan

3. Other Drugs Inducing Dry Mouth

Inhaled medications produce the sensation of dryness but without any change in the saliva flow.

The mechanism by which antacids work to produce dry mouth is not clear. Some of the antacids may affect the salivary glands by binding to a hyrogen-potassium ATPase pump.

 

11. Inhaled Medications

almost all

12. Antacids

Omeprazole, Cimetidine, Ranitidine

13. Pain relief drugs and Psychotropics

Atropine, Hyoscine, Morphine, Tramadol, Diazepam, Zopiclone

14. Anticancer Drugs

5-fluorouracil

15. Anti-HIV Drugs

Didanosine and some others

16. Others

Magnesium hydroxide, opthalmological, glucosamine

medications-that-cause-dry-mouth

How to Cure Dry Mouth Problems?

1. Reach Out to Your Pharmacist or Doctor

If you are suspecting your medications, your first step should be to check your medications with your pharmacist or a doctor. Your healthcare provider may ask you a few questions to know if your medications are responsible for causing dry mouth. If found to be true, he/she may take one of the following steps (if required)

  • Decrease the dose of your medication
  • Replace the medications with other medications that may not cause dry mouth
  • No changes in the medications should be made without first consulting with your doctor

2. Easy and Useful Remedies

  • Proper hydration
  • Increase in humidity at night-time
  • Avoidance of irritating dentrifices, hard and crunchy foods
  • Use highly purified lanolin-based moisturisers for lips.
  • Use commercially available sugar-free chewing gums and candies: Especially chewing gums increase saliva flow and decrease friction in your mouth.

4. Saliva Stimulants and Substitutes:

  • Choose a good gel, mouthwash, mouth spray and toothpaste suitable for your dry mouth problems.
  • It is preferred that the product contains components such as olive oil, betaine, xylitol, and vitamin E.
  • It is preferred if the product does not contain sodium lauryl sulfate, Cocamidopropyl betaine, and cinnamon.
  • Avoid using alcohol-based mouthwashes. Although the high alcohol content may help in killing germs faster, it reduces the amount of saliva in your mouth.
  • Lozenges containing mucin and anhydrous crystalline maltose are effective in treating dry mouth.

Biotene make products specifically for dry mouth patients including moisturising spray, oral rinse, gel, and lozenges form is very commonly used by people around the world.

Oasis moisturizing spray contains xylitol and glycerin components. The spray is alcohol-free and sugar-free.

I would also recommend saliva substitute gel, mouth spray and mouthwash by Xerostom.

Xylimelts are one of the best remedies I have known for dry mouth. They are like small discs like thing containing xylitol that you adhere to your teeth or gums. They come in mint-free and a mild mint flavour. They work well if you are looking for fast results. The only problem with these is that you will need to use them a lot more often than you think. Using twice in the night would help you sleep well.

Other Medications:

FDA approved two medications, pilocarpine and cevimeline for treatment of dry mouth. There are also prescription saliva substitutes and stimulants such as Neutrasal mouth rinse or Caphosol saliva substitute. You would need the assistance of your healthcare provider to know when and how to use these.

References

1. Barbe, A.G. (2018). Medication-Induced Xerostomia and Hyposalivation in the Elderly: Culprits, Complications, and Management. Drugs Aging 35, 877–885 (2018). https://doi.org/10.1007/s40266-018-0588-5

2. Shetty, S. R., Bhowmick, S., Castelino, R., & Babu, S. (2012). Drug induced xerostomia in elderly individuals: An institutional study. Contemporary clinical dentistry, 3(2), 173–175. https://doi.org/10.4103/0976-237X.96821

3. Vinayak V, Annigeri RG, Patel HA, Mittal S. (2013). Adverse affects of drugs on saliva and salivary glands. J Orofac Sci; 5:15-20

4. Proctor G.B. (2015) Medication-Induced Dry Mouth. In: Carpenter G. (eds) Dry Mouth. Springer, Berlin, Heidelberg

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.

© 2020 Sherry Haynes

Comments

Audrey Hunt from Idyllwild Ca. on April 02, 2020:

Excellent information and well written. I am on CPAP therapy and wake up every morning with terrible dry mouth. I'm guessing I sleep with my mouth open. I'll try Biotene and hope it helps.

Thanks so much.

Liz Westwood from UK on March 27, 2020:

This is a detailed and helpful article for anyone suffering with a dry mouth.

Umesh Chandra Bhatt from Kharghar, Navi Mumbai, India on March 26, 2020:

Nice article. Hydration is one important aspect.