Updated date:

Butyric Acid in the Body, Gut Bacteria, and Colon Health

Linda Crampton is a writer and teacher with a first-class honors degree in biology. She often writes about the scientific basis of disease.

An Important Chemical for Health

Our large intestine hosts a huge population of bacteria that have many effects on our lives. Most of these effects are believed to be beneficial. Some of our intestinal bacteria convert the soluble fiber and resistant starch present in undigested food into short-chain fatty acids. One of these fatty acids is butyric acid, which may have important health benefits in the large intestine. It helps to maintain a healthy intestinal lining and may reduce symptoms of inflammatory bowel disease. It may also lower the risk of colon cancer, though this benefit is less certain.

The colon is the longest section of the large intestine and houses the greatest number of gut bacteria. The amount of butyric acid formed in the colon depends on which bacteria live there and on how much soluble fiber and resistant starch is present. It’s also determined by the size of the bacterial population that is able to produce the butyric acid and by how long the fiber or starch stays in the colon. The study of gut bacteria and their needs and effects is very important. Keeping the bacteria healthy could also help to keep us healthy.

The Digestive Tract and Gut Bacteria

When food is swallowed, it passes through a tube called the digestive, gastrointestinal, or GI tract. The tube starts at the mouth and ends at the anus. The food is gradually digested as it travels. Digestion is the process in which food is broken down into small particles that can be absorbed.

The food that we eat gives us nutrition, but it also feeds the bacteria in our intestine. Most of these bacteria live in the colon. The small intestine and the rectum also contain bacteria, however. The concept of feeding both ourselves and our helpful gut bacteria is gradually becoming more popular. "Gut" is another word for the digestive tract or the intestine.

The general processes that occur in the digestive tract are as follows.

  • Food is digested in the mouth, stomach, and small intestine.
  • The products of digestion are absorbed through the lining of the small intestine into the bloodstream.
  • The blood carries the nutrients to where they're needed.
  • The indigestible food passes from the small intestine into the large intestine.
  • Bacteria in the large intestine act on the food residue, producing a variety of chemicals.
  • The lining of the large intestine absorbs water, salts, and vitamins.
  • The remaining food residue is released from the large intestine through the anus as feces (or stool).

Gut Bacteria in the Intestinal Microbiome

The Large Intestine and the Colon

The bacterial community in the colon is often referred to as the intestinal microbiome. Researchers are discovering that colon bacteria are very active. Many of them are beneficial. Some appear to be neutral and a few are harmful. In a healthy gut, the effects of the helpful bacteria overshadow the effects of the harmful ones. The study of gut bacteria is exciting because the bacteria may have profound effects on our lives and health.

The large intestine is made of the ascending colon, the transverse colon, the descending colon, and the rectum. Most of the bacteria live in the three sections of the colon, which are collectively known as simply "the colon".

Peas are a good source of soluble fiber.

Peas are a good source of soluble fiber.

What Is Soluble Fiber?

The human body can’t digest soluble fiber. This doesn't mean that the fiber is useless, however. In fact, it has health benefits. It dissolves in the water present in the digestive tract, forming a gel. This gel lowers the level of LDL cholesterol (the so-called “bad” cholesterol) in the blood. It also lowers the blood sugar level. Another health benefit of soluble fiber is that it can be fermented by certain colon bacteria to produce butyric acid.

Good sources of soluble fiber include barley, oatmeal, beans, peas, carrots, apples, pears (not including the peel), and many other types of fruits and vegetables. The peels of fruits and vegetables contain insoluble fiber. The body can't digest this material. Like soluble fiber, however, it has benefits, including bulking up the stool and relieving constipation.

Types of Dietary Fiber

What Is Resistant Starch?

Resistant starch is starch that we are unable to digest or that we digest very slowly. The amount of resistant starch in a food depends not only on the identity of the food but also on factors such as whether the food is cooked or raw, whether it's cooked and then cooled (which changes the nature of the starch), and its degree of ripeness. Some good sources of resistant starch are cooked potatoes that have been chilled, rice, pasta, unripe bananas, legumes such as navy beans and lentils, and high-amylose corn.

The glycemic index is a number that represents the ability of a food to raise the level of glucose in the blood. Glucose is the technical name for blood sugar. In general, food with a high glycemic index is considered to be bad, since it may lead to an increase in body fat and a higher risk of diabetes and heart attacks.

Resistant starch has little effect on blood sugar level and is therefore classified as a low glycemic substance. The glycemic index of a food containing resistant starch depends on the proportion of resistant starch to higher glycemic carbohydrates in the food. Some colon bacteria can ferment resistant starch to make butyric acid, which is another benefit of the substance.

Green bananas contain resistant starch. They're popular in some cuisines.

Green bananas contain resistant starch. They're popular in some cuisines.

This is the structural formula for a butyric acid molecule. The acid group is shown on the right side of the formula.

This is the structural formula for a butyric acid molecule. The acid group is shown on the right side of the formula.

What Is Butyric Acid?

A fat molecule is composed of a glycerol molecule joined to three fatty acid molecules. The whole structure is sometimes known as a triglyceride. Butyric acid, also called butanoic acid, is a fatty acid present in some triglycerides. It's released when the fat is broken down.

Some articles about butyric acid refer to butyrate. Butyric acid and the butyrate ion have slightly different structures, although they are very similar. The final hydrogen atom shown in the formula above has been lost in a butyrate ion, which is also called a butanoate ion. The ion can form substances called butyrate salts.

Butyric acid is a short-chain fatty acid, or SCFA, as opposed to a medium-chain or long-chain fatty acid. SCFAs have an acid group (COOH) at one end of their molecule and a “tail” or chain containing fewer than six carbon atoms attached to the acid group.

Some foods contain relatively high concentrations of butyric acid, including butter and parmesan cheese. The acid reportedly makes up 3% to 4% of butter. Kombucha tea also contains butyric acid. The kombucha culture is a mixture of bacteria and yeasts. If the culture is placed in tea that has been sweetened with sugar and the microbes are allowed to ferment the sugar, a variety of chemicals are produced, including butyric acid.

Parmesan cheese contains butyric acid. In Europe, parmesan cheese is another name for Parmigiano-Reggiano cheese.

Parmesan cheese contains butyric acid. In Europe, parmesan cheese is another name for Parmigiano-Reggiano cheese.

A Smelly Chemical

Butyric acid has a very unpleasant odor and smells like vomit. In fact, the chemical is present in vomit. When butter becomes rancid, enzymes produced by bacteria release the butyric acid from the fat molecules, producing the typical rancid smell. The acid got its name from “butyrum”, the Latin word for butter, which in turn was based on a similar Greek word.

Concentrated butyric acid must be handled very carefully, not only because of its nauseating smell but also because it’s corrosive. At low concentrations, however, the acid is safe. In very low concentrations, it’s used as a flavoring agent in food.

Butyrum is the Latin word for butter and gave rise to the term butyric acid.

Butyrum is the Latin word for butter and gave rise to the term butyric acid.

Potential Health Benefits of Butyric Acid

A saturated fatty acid contains only single bonds holding its atoms together. An unsaturated fatty acid contains one or more double bonds as well as single bonds. Saturated fats contain saturated fatty acids and have a reputation for creating health problems if eaten in excess. These problems include increasing the amount of LDL cholesterol in the blood. A high LDL cholesterol level may lead to fatty plaque deposits in arteries and increase the risk of a heart attack or a stroke. Excess cholesterol may also increase the risk of some types of cancer.

Although butyric acid is a saturated fatty acid, it's also a short-chain fatty acid and seems to have health benefits. It's the main food source of the colonocytes, which are cells in the lining of the colon. The chemical supports the colonocytes, helping them to function properly and maintaining the integrity of the intestinal lining. Some other SCFAs may also have health benefits. Short-chain fatty acids seem to have special benefits that other saturated fatty acids lack.

Butyric acid may help people suffering from Crohn’s disease and ulcerative colitis. These disorders are classified as inflammatory bowel diseases, or IBD. Butyric acid enemas have reduced colon inflammation symptoms in some IBD patients. Further exploration of this effect is needed, however.

Butyric Acid Enemas and Probiotics

Butyric acid enemas are sometimes offered to people with IBD. Unfortunately, the enemas smell bad and patients are not always willing to undergo the treatment. Another problem with an enema is that the butyric acid doesn’t stay in the colon for very long.

Researchers are investigating the use of probiotic supplements containing bacteria that can make butyric acid. If the probiotic bacteria multiply in the colon and become permanent inhabitants, the patient will have a continuous supply of a potentially useful chemical. A probiotic supplement should be much more pleasant to take than an enema.

Cooked and then chilled potatoes contain resistant starch, which increases the amount of butyric acid in the colon.

Cooked and then chilled potatoes contain resistant starch, which increases the amount of butyric acid in the colon.

Butyric Acid and Colon Cancer

Apoptosis—programmed cell death—is a normal process in cells. For example, cells may be stimulated to undergo self-destruction if their DNA is damaged so severely that it can’t be repaired or if there are too many cells in an area. Cancer cells do not undergo apoptosis and continue to multiply, however.

In some experiments with lab animals, butyric acid has been found to inhibit multiplication of cancerous colonocytes and stimulate apoptosis in the cells. Not all experiments concerning butyric acid and cancer have shown benefits. Nevertheless, the preliminary research results are intriguing.

The study of butyric acid or butyrate in relation to cancer is difficult. The surrounding environment seems to be very important in determining the effect of the chemical in the intestine. More research is needed before scientists agree that butyric acid can prevent or treat colon cancer in humans.

Oatmeal contains soluble fiber, which increases the amount of butyric acid in the large intestine.

Oatmeal contains soluble fiber, which increases the amount of butyric acid in the large intestine.

Increasing the Amount of Butyric Acid in the Colon

One plan for someone hoping to increase the amount of butyric acid in their colon is to eat foods that are high in soluble fiber and resistant starch. These substances should act as nutrients for appropriate gut bacteria. Since butter and parmesan cheese contain butyric acid, they could be used to support gut health as well. However, these foods also contains longer chained saturated fats, some of which may be unhealthy.

The recommendation from the majority of nutritionists and health agencies is to limit the amount of saturated fat in our diet. The suggestions for fat consumption in the American Heart Association article mentioned below are standard ones. The association says that research over many years has shown that saturated fats are bad for the cardiovascular system.

In the last few years, some dissenting opinions about saturated fats have arisen. Some researchers disagree with the idea that they are bad for the circulatory system and say that their demonization is wrong. Hopefully the situation will be clarified soon. The type of fat that we eat is an important topic for those of us that are concerned about our health.

Wheels of parmesan cheese maturing in a factory

Wheels of parmesan cheese maturing in a factory

The Importance of Supporting Gut Bacteria

Maintaining a helpful intestinal microbiome is very important. Scientists are learning more about the functions of bacteria in the colon and about how to add new ones to the intestinal population. It may one day be possible for us to eat or drink probiotic supplements that supply us with bacteria that will prevent or treat specific health problems. Until then, it seems like a good idea to support our present gut bacteria so that they can make substances that may provide significant health benefits, including butyric acid.

References

  • Soluble and insoluble fiber information from WebMD
  • Resistant starch facts from John Hopkins Medicine
  • Information about the glycemic index from Diabetes Canada
  • Butyric acid in irritable bowel syndrome from Przegla̜d Gastroenterologiczny and the U.S. National Library of Medicine (Includes a reference relating to the effect of butyric acid on intestinal inflammation in humans)
  • Potential beneficial effects of butyrate in intestinal and extraintestinal diseases from the World Journal of Gastroenterology
  • Butyrate and colorectal cancer from the NIH (National Institutes of Health)
  • The role of short-chain fatty acids in microbiota-gut-brain communication from nature.com (Abstract and Key Points)
  • American Heart Association recommendations for saturated fat intake

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.

Questions & Answers

Question: What are the side effects of butyric acid supplements?

Answer: If butyric acid supplements are being taken for a health problem, a doctor should either have prescribed them or know that the patient is taking them. The doctor will be able to discuss any potential benefits or side effects produced by a particular supplement in relation to the patient’s state of health. The doctor will also be able to recommend the correct dose of the supplement.

© 2011 Linda Crampton

Comments

Linda Crampton (author) from British Columbia, Canada on December 08, 2018:

Hi, Brian. Certain species of gut bacteria make butyric acid as the end-product of fermentation of undigested material in our gut. Fermentation is the process that the bacteria use to produce energy. When the butyric acid leaves their body, some of it is absorbed by the cells lining our colon and used.

Some species of bacteria in our gut may be able to use butyric acid, however. Supplementing with butyric acid may not affect the bacteria that produce it from fermentation, but it may affect any bacteria that use it.

The community of bacteria in our gut and their effects aren't completely understood. In addition, we don't know the ratio of particular species of bacteria in our own gut. It's probably better to rely on food if we hope to boost the butyric acid level in our colon instead of taking supplements, unless the supplements are recommended by a medical doctor. If a doctor does recommend the supplements, it would be a good idea to ask him or her some questions about their possible effects.

Brian W Corcoran on December 06, 2018:

Thank You for your response...my question concerning butyric acid is: doesn't it seem by supplementing with butyric acid by-passes the natural way the body is to create the acid and other various chemicals in the body...is Gut bacteria acting on the supplement (butyric acid)?...I don't see how supplementing with butyric acid can cause other Gut bacteria to produce what is needed to keep the Gut healthy...

Linda Crampton (author) from British Columbia, Canada on December 04, 2018:

Gut bacteria act on the indigestible food that enters the large intestine, producing various chemicals. In a normal diet, there are always indigestible components in the food that's eaten, so there are always components available for the bacteria.

In addition, anyone who eats at least some plants consumes fibre from the plants, whether or not they take butyric acid supplements.

Brian Corcoran on December 01, 2018:

You stated the following: -

The indigestible food passes from the small intestine into the large intestine. Bacteria in the large intestine act on the food residue, producing a variety of chemicals.

QUESTION: if bacteria in the large intestine act on the food residue, producing a variety of chemicals, how will these chemicals be produced if an individual is supplementing with butryic acid instead of consuming fiber?

Linda Crampton (author) from British Columbia, Canada on September 28, 2016:

Thanks for the comment, Gershon. Butyric acid is absorbed into the body through the lining of the small intestine, but based on the research reports that I've seen the chemical is usually studied with respect to its effects on the large intestine. Encapsulated supplements containing butyric acid are currently available. They're designed to release their contents in the intestine, but I don't know how effective they are.

Gershon on September 27, 2016:

I appreciated your article. Thanks! Can you tell me...what type of effect should butyric acid have on the small intestines? Any? Also, any experience with butyric acid supplementation or familiar with its effects?

Linda Crampton (author) from British Columbia, Canada on May 30, 2016:

What an interesting question! As far as I know, the answer is no. Only a small amount of butyric acid enters the bloodstream from the intestine. Most of it is used by cells lining the colon. Butyric acid can cause difficulty in breathing when it's inhaled, but only if it's very concentrated.

Jackie on May 30, 2016:

While consuming these saturated fats that produce butyric acid, is it possible for someone to emit an odor that can cause another person to have a reaction involving difficulty breathing, tight chest, and wheezing?

Linda Crampton (author) from British Columbia, Canada on November 14, 2012:

Hi, Paolo Pezzi. Thanks for the comment. Most nutrition experts recommend that we limit our consumption of foods containing a high level of saturated fat, because there is a lot of evidence that these foods contribute to health problems if they are eaten (or drunk) in a large amount. The problem is that there are many types of saturated fatty acids in foods, and while some are harmful others seem to be beneficial! Omega-3 fats are considered to be very good for us, though.

Paolo Pezzi on November 14, 2012:

Very good article! Only a consideration: do not limit milk derivates for saturated fatty acids but integrate the diet with omega-3 (like fish or linseed oils). Milk cream is better than butter for a higher content in phospholipids (lecithines).

Linda Crampton (author) from British Columbia, Canada on October 21, 2012:

Thank you, PaisleeGal. I appreciate the comment and the vote!

Pat Materna from Memphis, Tennessee, USA on October 21, 2012:

Alicia.. good article and useful information. Thanks for sharing. Voted up!

Linda Crampton (author) from British Columbia, Canada on May 01, 2011:

Thank you so much, prasetio! Best wishes - I hope that this week will be a great one for you.

prasetio30 from malang-indonesia on May 01, 2011:

Hi, Alicia. I always learn something new from you. Thanks for share with us. I'll press all button here, except funny. Take care!

Blessing and hugs,

Linda Crampton (author) from British Columbia, Canada on April 29, 2011:

Thanks, CMHypno! I eat bananas that are slightly green, too. I don't like bananas when they are very ripe, unless they are mixed with other ingredients in a smoothie.

CMHypno from Other Side of the Sun on April 29, 2011:

Thanks for the great information AliciaC. I have always preferred my bananas on the green side, so I am glad to know that I have been making a healthy choice!

Linda Crampton (author) from British Columbia, Canada on April 28, 2011:

Thanks for the visit and the comment, Peggy W. I get probiotics from yogurt, which I eat frequently. I buy brands of yogurt that contain live bacterial cultures. I only eat butter occasionally (I like it too much to eat in moderation!) so I'm not getting butyric acid from this source. I hope that my gut bacteria are making butyric acid for me!

Peggy Woods from Houston, Texas on April 28, 2011:

I have been hearing more and more about probiotics. Do you take some on a daily basis or just rely upon food sources? If the former...any certain brands? You mentioned butter. What about yogurt? Thanks for this interesting hub!

Linda Crampton (author) from British Columbia, Canada on April 26, 2011:

Hi, b. Malin. I hope you feel better soon. Not being sick for years is very impressive! Thank you so much for your comment.

b. Malin on April 26, 2011:

I'm just getting over the Flu...I haven't been sick in YEARS...SO, needless to say how very helpful this Hub was to me. Thanks so much for sharing.